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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.1 mg per day and the corresponding doses in patients receiving a different dose of prednisolone. The researchers also identified that treatment with prednisolone had a potential effect on the metabolism of insulin. But prednisolone may not be particularly effective at stimulating insulin growth factor (IGF). The research team speculated that there might already be other ways of increasing insulin response and metabolism than using prednisolone, or that perhaps insulin levels are already low enough that no further treatment is needed but that prednisolone treatment was needed in order to compensate. The researchers also reported that, when they examined the patients' blood insulin levels before and one month after receiving prednisolone, there was no change in this level; at the time of the study, the patients' levels were about 8-fold greater than normal, and there was a significant decrease over the time of this study in terms of both insulin sensitivity and insulin production. But when the researchers followed the patients up one month later, there were no signs of insulin sensitization. "These data demonstrate that prednisolone administration in individuals with T2DM may have an effect on serum insulin response that is independent of the magnitude of the insulin concentration, and independent of the type of pancreatic β cell insulin-producing cell that is active in this tissue," they concluded. The researchers caution that more work needs to be done to determine the long-term effects of prednisolone on the metabolism of insulin, as well as its ability to stimulate IGF levels. Similar articles:
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